Non-Invasive Intracranial Pressure Monitoring via Parametric Acoustic Arrays

Overview

Intracranial pressure (ICP) monitoring is critical in managing traumatic brain injury and hydrocephalus, yet current gold-standard methods require invasive catheter insertion. This work investigates the feasibility of a parametric acoustic array approach for non-invasive ICP estimation through the intact skull.

Key Contributions

• Developed a theoretical framework coupling parametric array generation with transcranial wave propagation to extract ICP-correlated signatures.
• Conducted numerical simulations demonstrating sensitivity of nonlinear self-demodulation signals to changes in intracranial compliance.
• Proposed a signal processing pipeline for extracting pressure-dependent spectral features from received waveforms.

Methods & Tools

• GPU-accelerated nonlinear acoustic simulation (MATLAB, Python)
• Multi-channel ultrasound data acquisition (Verasonics)
• SVD-based spatiotemporal filtering for clutter suppression

Status

Manuscript in preparation. Target journal: IEEE Transactions on Biomedical Engineering or Physics in Medicine & Biology.

Citation

Dash, P. P., & Arvanitis, C. D. (2026). Non-Invasive Intracranial Pressure Monitoring via Parametric Acoustic Arrays: A Feasibility Study. (In preparation).